
blazer, broaches + rings. Maison Simons
sweater + top. COS
glasses. Talent’s Own
Nico Santos has built a career on proving it’s one of the sharpest tools for survival and joy. Born and raised in the Philippines before moving to the United States as a teenager, the actor and comedian turned culture shock into creative fuel. What began as a way to navigate the uneasy terrain of high school and identity has since become his superpower: a sense of humour that bridges worlds and celebrates authenticity in all its forms.
From his breakout role as Mateo in Superstore to scene-stealing turns in ‘Crazy Rich Asians’ and ‘Guardians of the Galaxy Vol. 3’, Santos has carved out space for queer, Filipino stories on screens big and small; always with a wink, a punchline, and a generous dose of heart. But behind the comedy lies a grounded storyteller, one who knows the sting of silence after a bad set, the grind of restaurant shifts between auditions, and the quiet triumph of affording an apartment with “in-unit laundry” after years of hustling.
Now reprising his fan-favourite role as René on ‘St. Denis Medical’, Santos returns to the mockumentary world that feels, as he puts it, “like home.” Between takes, he’s still that sharp, self-aware performer who once used humour as armour, but these days, he’s wielding it as a spotlight.
You grew up in the Philippines and moved to the U.S. at a young age. How did that cultural shift shape your sense of humour and the way you approach comedy?
I was exposed to a lot of American culture growing up, so I had some understanding of what American humour was like. But being in a new country—and how drastic that change was—I mean, I moved a week before high school started. Being funny was like a Swiss army knife. [laughs] It’s your armour, your weapon, your validation. It’s how you express or suppress feelings. It becomes your name tag, your identity. I think every queer kid has experienced some type of bullying, so it made me realize, “Oh, I can use this to my advantage.” I mean, who doesn’t love to laugh?
You started doing stand-up in San Francisco before landing major TV and film roles. What was the toughest crowd you faced early on, and how did it shape your craft?
Oh, I’ve bombed so many times. [laughs] There was that one time I was contracted to do an hour-long set for a college and no one laughed. But I had to do the full hour or else I wasn’t going to get paid. You just have to endure it. That’s how you get better.
Can you recall your first big break or “aha” moment when you realized acting could be more than a hobby?
Superstore was definitely my big break. I had only done four or five acting jobs before, and they were all small roles. I mean, there’s no such thing as job security when you’re an actor. [laughs] I still kept my day job as a restaurant host while filming part of the first season of Superstore. Eventually, everyone was like, “You’re not making $11 an hour anymore. You can quit picking up shifts on weekends.” But honestly, after being a broke comedian for so long, the moment I was finally able to afford to live alone and get an apartment with in-unit laundry, I thought, I think I might stay a while. [laughs]

blazer. Hugo Boss @ Gotstyle
shirt + trousers. Maison Simons
shoes. Paul Smith
glasses. Soup Cans @ Gotstyle
bow tie. Gotstyle
opposite
blazer, shirt + necklace. Maison Simons
glasses. Talent’s Own
flower broach. Mayer
Your stand-up often features quirky characters and sharp observations. How much of that early comedy work informs the roles you play today?
While I’ve definitely played a few different characters, I would say that most of the roles I play are versions of myself. It’s important to me to play characters that highlight my Filipino and queer culture and experience. Representation matters. That sounds cliché, but it’s true, and it’s something we need to nourish and protect—especially in today’s climate, where immigrants and the queer and trans community are under attack. You can’t make us disappear. We’re not going anywhere.
Coming from a background in stand-up, what was the most surprising thing about transitioning to scripted television and film?
The silence. [laughs] As a stand-up comic, you’re conditioned to wait for the laugh. Filming my first scene and not getting an instant reaction was something I had to get used to as a performer. Everyone on set is taught to do their job and maintain their composure. This is the same reason why auditions were tricky for me in the beginning.
You’ve had such a range—from ‘Crazy Rich Asians’ to ‘Guardians of the Galaxy Vol. 3’ to ‘Superstore’. How do you choose projects, and what draws you to a role?
One thing about the entertainment industry is that you get to work with your friends. I love the feeling of being on set and creating something with people you’ve known since you were broke, eating ramen, and had no furniture in your apartment.
You’ve worked in ensemble casts with incredible talent across comedy and action genres. Do you have any memorable on-set stories or pranks that stand out?
My favourite would be when we were doing a night shoot for the Superstore pilot. We were filming inside a Kmart, and around 3:30 or 4 a.m., the delirium set in. We just became ridiculously silly between takes—singing and dancing like idiots, grabbing things from the racks and doing runway challenges. It was like Lord of the Flies but with unstable actors. [laughs] Our showrunner even ended up writing an episode about it: Season 1’s “All-Nighter.”
What’s a role or project you’ve done that fans might be surprised to learn about, but that really challenged you as an actor?
I did an indie comedy titled ‘The Re-Education of Molly Singer’ where I played my most challenging role yet… a top. [laughs] I also did an Off-Broadway play written by Jesse Eisenberg with Susan Sarandon once. The last time I did a play was in college, about 20 years ago. My hat goes off to every actor out there living that eight-shows-a-week life. That is hard. But the juice was worth the squeeze.

jacket. Mayer
shirt. Horst @ Gotstyle
shorts, socks + tie. Maison Simons
shoes. Browns
opposite
blazer. Strellson @ Gotstyle
top + trousers. Mayer
shoes. Browns Shoes
You’re reprising your role as René on ‘St. Denis Medical’. How has stepping back into this character been different from your previous appearances?
For recurring roles like these, I find it’s the writing that helps me find the character again. And so many people from Superstore now work on St. Denis—writers, camera crew, background actors, cast, every department! It makes it even easier to step onto set because it feels like home.
René is known for his sarcastic wit and outrageous sensibility. How do you balance that humour with the medical drama setting of the show?
Well, I think it’s pretty clear there’s no drama to balance with. [laughs] It’s a half-hour network mockumentary. You want drama, go watch ‘Grey’s Anatomy’.
Without giving away spoilers, can you tease a funny or unexpected moment viewers should look forward to in your guest stint?
You never know with René… You’ll just have to tune in.

shirt. Mayer
trousers + scarf. Maison Simons
shoes. Browns
glasses. Talent’s Own
‘St. Denis Medical’ is airing now.
photography. Matthew Lyn
fashion. Cynthia Florek
hair. James Dunham
make up. Ian Russell using NARS
prop styling + set design. Erica Morga @ Cadre Artist Management
post production. Rebecca Van Ommen @ Paperboat Retouching
photography assistants. Samuel Engelking, Zeynel Akkus + Natalie Levin














